San Francisco 49ers at Indianapolis Colts: final score & recap
San Francisco 49ers beat Indianapolis Colts 48-27 in Week 16. San Francisco 49ers out-gained Indianapolis Colts 440 to 312 total yards. San Francisco 49ers won the turnover battle.
48-27
Final score
SF at IND
12-5
SF record
2025 season
8-9
IND record
2025 season
32.6
Top performer
Christian McCaffrey · 32.6 PPR pts
TUE, DEC 23, 2025
48 – 27
Lucas Oil Stadium
Score by quarter
Team stats
Box scoreTotal yards
Passing yards
Rushing yards
Red zone4-6 (67%) / 2-2 (100%)
3rd down7-11 (64%) / 5-10 (50%)
Time of possession33:05 / 26:55
Turnovers1 / 2
Top performers
21 car · 117 yds · 6/8 rec · 29 yds · 2 TD
32.6
Brock Purdy QB
25/34 · 295 yds · 5 TD · 2 car · 11 yds
30.9
7/8 rec · 115 yds · 1 TD
24.5
Alec Pierce WR
4/4 rec · 86 yds · 2 TD
24.6
23/35 · 277 yds · 2 TD
17.1
16 car · 46 yds · 1 TD · 3/3 rec · 33 yds
16.9
Key plays
api-sports /games/eventsFirstTDAlec Pierce 20 Yd pass from Philip Rivers (Blake Grupe Kick)0-7
FirstTDDemarcus Robinson 22 Yd pass from Brock Purdy (Eddy Pineiro Kick)7-7
FirstTDChristian McCaffrey 2 Yd pass from Brock Purdy (Eddy Pineiro Kick)14-7
SecondTDAlec Pierce 16 Yd pass from Philip Rivers (Blake Grupe Kick)14-14
SecondTDGeorge Kittle 11 Yd pass from Brock Purdy (Eddy Pineiro Kick)21-14
SecondFGEddy Pineiro 25 Yd Field Goal24-14
SecondFGBlake Grupe 39 Yd Field Goal24-17
ThirdTDJauan Jennings 3 Yd pass from Brock Purdy (Eddy Pineiro Kick)31-17
ThirdFGBlake Grupe 51 Yd Field Goal31-20
ThirdFGEddy Pineiro 38 Yd Field Goal34-20
FourthTDJonathan Taylor 1 Yd Rush (Blake Grupe Kick)34-27
FourthTDChristian McCaffrey 9 Yd pass from Brock Purdy (Eddy Pineiro Kick)41-27
FourthTDDee Winters 74 Yd Interception Return (Eddy Pineiro Kick)48-27
Game info
KickoffTue, Dec 23, 2025
VenueLucas Oil Stadium
Week16